-Major systemic disease
-Age inappropriateness (70 years of age)
-Cancer in the last 5 years except localized skin (not melanoma) or stage I breast or prostate
-Active smoker (less than 6 months since quitting)
-Active substance abuse
-HIV
-Severe local or systemic infection
-Severe neurological deficits
-Major psychiatric illness or active substance abuse that cannot be managed sufficiently to allow post-transplant care and safety
