In individuals homozygous for a tandem duplication, two homologous chromosome with duplications can pair out of register during meiosis. Such homologs can undergo unequal crossing-over.
Unequal crossing over is a type of gene duplication that deletes a sequence in one strand and replaces it with a duplication from its sister chromatid in mitosis or from homologous chromosome during meiosis
Repeated rounds of unequal crossing over causes homogenization of the two sequences. With the increase in the duplicates, unequal crossing over may cause dosage imbalance in the genome that can prove to be highly deleterious.
To know more about crossing over, refer
https://brainly.com/question/927405
#SPJ4
